The Royals jumped out to a four-run lead, but could not hold it in a 5-4 loss to the Tigers in Detroit.
Maikel Franco had three KC hits and drove in a pair of runs. Whit Merrifield had two hits and scored two runs.
Starter Danny Duffy struck out eight in five innings, allowing four runs in a no-decision. Ian Kennedy took the loss in relief.
The two teams wrap up a four-game series today in Detroit with rookie Brady Singer starting for the Royals.