The Blues outshot Chicago 36-27, but went 0-for-6 on the power play and finished 2-for-29 in the series. Their failure to convert with the man advantage came back to haunt them as the Blackhawks scored four goals in the third period to break a 1-1 tie, to win 5-1 in game six of their first round playoff series.
The defending Stanley Cup champion Blackhawks beat their rival 4-2 in the series after dropping the first two games.
Duncan Keith had a goal and three assists and Corey Crawford made 35 saves as Bryan Bickell, Jonathan Toews, Patrick Sharp and Andrew Shaw also scored for Chicago.
T.J. Oshie scored the Blues lone goal to tie the game at 1-1 with 3:32 left in the first period. The Blues dominated the second period thanks to four power plays, including a four-minute advantage after Marian Hossa was given a double minor at 7:15 for high-sticking Alex Steen. Part of that power play was disrupted after Steen got called for penalty.
They outshot the Blackhawks 17-3 in the second and held a 28-11 advantage in shots starting the third, but the Hawks scored two goals in the first 2:01 of the third to take control of the game.