Lonnie Chisenhall’s first career grand slam broke open a 1-0 game as the Cleveland Indians handed the Royals a 5-3 loss on Saturday night.

Down 1-0, Royals starter Jeremy Guthrie ran into trouble in the sixth when Jason Kipnis started with a leadoff single in the sixth. Michael Brantley’s one-out double moved Kipnis to third and Carlos Santana was intentionally walked. Guthrie struck out Jason Giambi, but Chisenhall hit the first pitch he saw. It was the the 22nd home run allowed by Guthrie, tying him for the American League lead.

Scott Kazmir allowed two runs in 6.1 innings for his first victory since June 21, but he is 5-0 at home. The Royals scored three in the seventh to close the gap.