The Chicago Cubs knocked Lohse around for six runs in the 4th and beat the Cardinals a 9-3 in front of a record crowd of 46,792 at Busch Stadium.
Chicago broke the game open in the fourth when right fielder Kosuke Fukudome had an RBI double to right, catcher Geovany Soto hit a two-run double to center field and second baseman Mike Fontenot had a three-run home run to right field, his second of the year.
Fontenot’s home run was the first Lohse allowed in 37 2/3 innings this season.
The Cardinals answered with single runs in the fourth, fifth and sixth.
The Cardinals fell to 19-12 on the season. The Cubs improved to 18-12, a half game behind the Cards. The teams will meet in the final game of the series at 7:05 p.m. on Sunday in a nationally-televised game on ESPN.