#3 Northwest Missouri 33, East Central 3

#3 Northwest Missouri overcame four turnovers by forcing four of their own on the way to a 33-3 season opening victory over East Central. The Bearcat defense held ECU to just 292 yards of total offense and only 48 yards on the ground. Trevor Adams threw for 201 yards and a touchdown also scoring one on the ground while Brandon Dixon had two interceptions.

#18 Missouri Western 38, Central Missouri 26

#18 Missouri Western led 28-7 at the half and held off a second half charge by Central Missouri to pull out a 38-26 season opening victory. The Griffons took advantage of three interceptions scoring both their second quarter touchdowns off turnovers.

Truman 24, Southwest Baptist 14

The Truman Bulldogs took advantage of five SBU turnovers to pull out a 24-14 victory on the road. TSU jumped out to a 21-0 advantage in the third quarter before the Bearcats scored 14 unanswered to cut the lead to a single touchdown. Garrett White scored two touchdowns racking up 109 yards of total offense for TSU. Conrad Schottel was 14-32 for 221 yards through the air. For the Bearcats Dan Connors was 20-45 for 176 yards and had one touchdown through the air and one on the ground. 

Missouri Southern 25, Central Oklahoma 20

Missouri Southern took a 25-7 lead into the fourth quarter but Central Oklahoma put up 13 points to come up just shy of the comeback losing 25-20 at home. The two teams both ended up with less than 300 yards and the game saw five total turnovers. For Central Oklahoma Adrian Nelson threw for 148 yards and a touchdown while Brandon Williams had 3.5 tackles and an interception. For the Lions Kellen Cox threw for 43 yards and rushed for 89 yards and a touchdown.